![]() ![]() The incidence of Vitiligo in India is also quite high, varying in the range of 3%-4%, and as high as 8.8%. Vitiligo is increasing at a high rate in the world, affecting about 1% of the people throughout the world. Clearly suggesting that there is no pinpoint cause of Vitiligo, which can be prevented. Even Free Radical Hypothesis mentions that there may be presence of oxidative stress which can interact with the intermediates in melanin synthesis, again resulting in destruction of Melanocytes. Neural Hypothesis states that there may be certain toxic neurotransmitters that destroy melanocytes. ![]() Immune Hypothesis states that there is evidence which points towards autoimmunity, which means our own Immune cells destroy Melanocytes resulting in destruction of melanocytes. These include- Genetic Factors- which means Vitiligo patients may have a Positive Family history (20-30%), which means it can run in Families. As it is an autoimmune disease, no exact cause can be identified, yet different theories have been introduced which can be the cause of Vitiligo. Defect in Vitiligo is usually Melanocytopenia. The cause of Vitiligo is not exactly known, and there are different patterns of Vitiligo which may have different etiology. Vitiligo is an Autoimmune Hypopigmentary disorder, which manifests lack or destruction of Colour producing cells (melanocytes). ![]() Apart from pigments of skin, even blood flow in the skin also determines its colour. They contain discrete organelles called Melanosomes, which actually synthesize Melanin. Melanocytes are present in the basal layer of epidermis. Skin colour mainly depends on pigments present in the skin, among them, the most important pigment is Melanin, which is synthesized by Melanocytes, apart from the presence of several Chromophores. Vitiligo (Safed Daag) is a Skin disease manifested by Depigmentation (loss of colour) of skin. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |